Table 2.
Primary and secondary outcomes by LAAC status
| No-LAAC | LAAC | IPTW method | P-value | |
|---|---|---|---|---|
| n = 70 629 | n = 1351 | HR (95% CI) | ||
| Primary efficacy outcome | 5.4% | 2.5% | 0.38 (0.17–0.88) | 0.024 |
| Primary safety outcome | 6.8% | 2.9% | 0.39 (0.23–0.66) | 0.001 |
| Ischaemic stroke | 1.9% | 0.8% | 0.20 (0.04–1.12) | 0.067 |
| Intracerebral haemorrhage | 0.2% | 0.0% | NA | <0.001 |
| All-cause mortality | 3.5% | 2.6% | 0.48 (0.19–1.23) | 0.124 |
| Major bleeding | 6.0% | 1.6% | 0.34 (0.18–0.64) | 0.001 |
| Gastrointestinal bleeding | 1.3% | 0.2% | 0.22 (0.06–0.79) | 0.020 |
| Blood transfusions | 4.90% | 2.10% | 0.37 (0.19–0.73) | 0.004 |
| Admission for bleeding | 2.30% | 0.50% | 0.20 (0.07–0.58) | 0.003 |
| Pericardiocentesis | 0.30% | 0.20% | 0.44 (0.06–3.19) | 0.42 |
| Cardiac tamponade | 0.30% | 0.50% | 1.33 (0.41–4.35) | 0.635 |
| Heart failure hospitalizations | 13.2% | 6.4% | 0.52 (0.33–0.82) | 0.005 |
The primary efficacy outcome was a composite of ischaemic or haemorrhagic stroke, TIA, and/or mortality.
The primary safety outcome was a composite of major bleeding, pericardiocentesis, and pericardial tamponade.
Major bleeding was a composite of intracranial haemorrhage, gastrointestinal bleeding, blood transfusion, and/or admission for bleeding.
Cumulative percentages using Kaplan–Meier curve time-to-event analysis.
Cox-proportional hazards regression model was used to generate hazard ratios.
CI, confidence interval; HR, hazard ratio; IPTW, inverse probability of treatment weighting; LAAC, left atrial appendage closure.