Table 1.
Baseline characteristics of all patients with Brugada syndrome stratified by disease manifestation
| Asymptomatic or unspecified disease manifestation (n = 122) | Symptomatic disease manifestation (n = 101) | All (n = 223) | P-value | |
|---|---|---|---|---|
| Sex (male) | 84 (68.9) | 78 (77.2) | 162 (72.6) | 0.2 |
| Age at diagnosis | 45.8 (30.3, 57.4) | 46.1 (32.6, 55.9) | 46 (32.2, 57.1) | 0.6 |
| ICD implanted | 18 (14.8) | 61 (60.4) | 79 (35.4) | < 0.0001 |
| Disease manifestation | ||||
| Asymptomatic or unspecified | 122 (100) | — | 122 (54.7) | |
| Symptomatic (total) | — | 101 (100) | 101 (45.3) | |
| Syncope | — | 56 (55.4) | 56 (25.1) | |
| Ventricular tachycardia | — | 17 (16.8) | 17 (7.6) | |
| Aborted cardiac arrest | — | 28 (27.7) | 28 (12.6) | |
| Social factors | ||||
| Living together/cohabiting | 82 (68.3) | 69 (69.7) | 151 (68.9) | 0.9 |
| Education level 1—ISCED 0–2, basic school | 23 (20.4) | 21 (21.9) | 44 (21.1) | |
| Education level 2—ISCED 3, high school or vocational education | 55 (48.7) | 47 (49.0) | 102 (48.8) | |
| Education level 3—ISCED 5–8, higher education | 35 (31.0) | 28 (29.2) | 63 (30.1) | 0.9 |
| Comorbidities | ||||
| Cancer | 4 (3.3.) | 5 (5.0) | 9 (4.0) | 0.8 |
| Hypertension | 9 (7.4) | 14 (11.6) | 20 (9.0) | 0.5 |
| Ischemic heart disease | 7 (5.7) | 5 (5.0) | 12 (5.4) | 1 |
| Atrial fibrillation | 10 (8.2) | 6 (5.9) | 16 (7.2) | 0.7 |
| Concomitant pharmacotherapy (90 days prior to diagnosis) | ||||
| Beta blockers | 10 (8.2) | 13 (12.9) | 23 (10.3) | 0.4 |
| Calcium antagonist | 4 (3.3) | 7 (6.9) | 11 (4.9) | 0.3 |
| ACE inhibitor | 6 (4.9) | 6 (5.9) | 12 (5.4) | 1 |
ICD, implantable cardioverter defibrillator; ISCED, International Standard Classification of Education.