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. Author manuscript; available in PMC: 2024 Feb 1.
Published in final edited form as: Eur Urol. 2022 Sep 16;83(2):112–120. doi: 10.1016/j.eururo.2022.08.010

Fig. 1 –

Fig. 1 –

Overview of Epic Sciences’ single-CTC sWGS methodology in which nucleated cells are extracted from whole blood, plated onto slides, stained (CK, DAPI, and CD45), and scanned for CTCs using automated imaging software. Individual CTCs are isolated from the slides for DNA extraction and sWGS. CTC = circulating tumor cell; ctDNA = circulating tumor DNA; sWGS = shallow whole-genome sequencing.