(A) The CI control should indicate a band of high molecular weight DNA. (B) The DC and Hi-C samples show a range of DNA sizes. The Hi-C sample, having been combined into larger fragments, should be of higher molecular weight than the DC. The concentration range of markers allows for generating a standard curve. Note, in this example, the CI was loaded on a separate gel, but it is advised to load and run all samples and controls together. Abbreviations: CI = chromatin integrity; DC = digestion control; Hi-C = proximity-ligated.