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. 2023 May 16;14:1163633. doi: 10.3389/fimmu.2023.1163633
PD-1 programmed cell death 1
PD-L1 programmed cell death 1 ligand 1
PD-L2 programmed cell death 1 ligand 2
MHC major histocompatibility complex
TCR T cell receptor
APCs antigen-presenting cells
CTLA-4 cytotoxic T lymphocyte-associated antigen-4
CD28 cluster of differentiation 28
CD80 cluster of differentiation 80
Gal-9 galectin-9
TIM-3 T cell immunoglobulin and mucin domain 3
irAEs immune-related adverse events
Ig immunoglobulin
ITIM immunoreceptor tyrosine-based inhibitory motif
ITSM immunoreceptor tyrosine-based switch motif
ICOS inducible co-stimulatory molecule
NFAT nuclear factor of activated T cells
FOX Forkhead box protein
IRF9 interferon regulatory factor 9
CTLs cytotoxic T lymphocytes
PI3K phosphoinositide 3-kinase
PDK1 phosphoinositide-dependent kinase 1
mTOR mammalian target of rapamycin
MAPKK mitogen-activated protein kinase kinase
ERK extracellular-signal-regulated kinase
JAKs Janus kinases
STAT signal transducers and activators of transcription
VISTA V-domain Ig suppressor of T cell activation
CRD carbohydrate-recognition domain
PD-1H programmed cell death 1 homolog
PSGL-1 P-selectin glycoprotein ligand 1
VSIG3 V-set and Ig domain-containing 3
IFN-γ interferon gamma
RGMb repulsive guidance molecule b
GPI glycosylphosphatidylinositol
BMP bone morphogenetic proteins
Hh Hedgehog
FDA Food and Drug Administration
PTM Post-transcription modification
IBD inflammatory bowel disease
SLE systemic lupus erythematosus
T1D Type 1 diabetes
TLR toll-like receptor
IFN-1 type I interferon
ANCA antineutrophil cytoplasmic antibody
IBM inclusion body myositis
PM polymyositis
mAbs monoclonal antibodies
aGVHD acute graft versus host disease
LCMV lymphocyte choriomeningitis virus
HIV human immunodefficiency virus
HBV hepatitis B virus
HCV hepatitis C virus
COVID-19 coronavirus disease 2019
Tregs regulatory T cells
EBV Epstein-Barr virus
CAEBV chronic active Epstein-Barr virus infection
allo-HSCT allogeneic hematopoietic stem cell transplantation
Mbt Mycobacterium tuberculosis
MDSCs myeloid derived suppressor cells
FKBP FK506-binding protein
LCN2 Lipocalin 2
map-PD-L1 membrane-anchored-protein PD-L1
Th2 T helper type 2
AHR airway hyperreactivity
GTN gestational trophoblastic neoplasia
ICIs immune checkpoint inhibitors.