PD-1 |
programmed cell death 1 |
PD-L1 |
programmed cell death 1 ligand 1 |
PD-L2 |
programmed cell death 1 ligand 2 |
MHC |
major histocompatibility complex |
TCR |
T cell receptor |
APCs |
antigen-presenting cells |
CTLA-4 |
cytotoxic T lymphocyte-associated antigen-4 |
CD28 |
cluster of differentiation 28 |
CD80 |
cluster of differentiation 80 |
Gal-9 |
galectin-9 |
TIM-3 |
T cell immunoglobulin and mucin domain 3 |
irAEs |
immune-related adverse events |
Ig |
immunoglobulin |
ITIM |
immunoreceptor tyrosine-based inhibitory motif |
ITSM |
immunoreceptor tyrosine-based switch motif |
ICOS |
inducible co-stimulatory molecule |
NFAT |
nuclear factor of activated T cells |
FOX |
Forkhead box protein |
IRF9 |
interferon regulatory factor 9 |
CTLs |
cytotoxic T lymphocytes |
PI3K |
phosphoinositide 3-kinase |
PDK1 |
phosphoinositide-dependent kinase 1 |
mTOR |
mammalian target of rapamycin |
MAPKK |
mitogen-activated protein kinase kinase |
ERK |
extracellular-signal-regulated kinase |
JAKs |
Janus kinases |
STAT |
signal transducers and activators of transcription |
VISTA |
V-domain Ig suppressor of T cell activation |
CRD |
carbohydrate-recognition domain |
PD-1H |
programmed cell death 1 homolog |
PSGL-1 |
P-selectin glycoprotein ligand 1 |
VSIG3 |
V-set and Ig domain-containing 3 |
IFN-γ |
interferon gamma |
RGMb |
repulsive guidance molecule b |
GPI |
glycosylphosphatidylinositol |
BMP |
bone morphogenetic proteins |
Hh |
Hedgehog |
FDA |
Food and Drug Administration |
PTM |
Post-transcription modification |
IBD |
inflammatory bowel disease |
SLE |
systemic lupus erythematosus |
T1D |
Type 1 diabetes |
TLR |
toll-like receptor |
IFN-1 |
type I interferon |
ANCA |
antineutrophil cytoplasmic antibody |
IBM |
inclusion body myositis |
PM |
polymyositis |
mAbs |
monoclonal antibodies |
aGVHD |
acute graft versus host disease |
LCMV |
lymphocyte choriomeningitis virus |
HIV |
human immunodefficiency virus |
HBV |
hepatitis B virus |
HCV |
hepatitis C virus |
COVID-19 |
coronavirus disease 2019 |
Tregs |
regulatory T cells |
EBV |
Epstein-Barr virus |
CAEBV |
chronic active Epstein-Barr virus infection |
allo-HSCT |
allogeneic hematopoietic stem cell transplantation |
Mbt |
Mycobacterium tuberculosis |
MDSCs |
myeloid derived suppressor cells |
FKBP |
FK506-binding protein |
LCN2 |
Lipocalin 2 |
map-PD-L1 |
membrane-anchored-protein PD-L1 |
Th2 |
T helper type 2 |
AHR |
airway hyperreactivity |
GTN |
gestational trophoblastic neoplasia |
ICIs |
immune checkpoint inhibitors. |