FIGURE 3.

Consensus sequences used in the classification of major versus minor introns. Here, we schematize splice site selection by the respective components of the major and minor spliceosomes. The snRNAs of the major (U1 and U1) and minor (U11 and U12) spliceosome are shown base pairing to their cognate consensus sequences. In the center, next to the respective major intron and minor intron labels, we depict consensus sequences as nucleotide frequency plots. Here, the relative size of the nucleotide represents how frequently it is observed in that genomic position. Right of this schematic, we include the remaining core snRNAs that are unique to major (U4 and U6) and minor (U4atac and U6atac) intron splicing, as well as the shared U5 snRNA.