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. 2023 May 16;17:1148950. doi: 10.3389/fnins.2023.1148950

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Copyright © 2023 Wareham, Holden, Bossardet, Baratta, Del Buono, Schlumpf and Calkins.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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CMP 03A preserves the integrity of the corneal epithelial cell layer. Examples of fluorescence intensity and first-derivative line plots, respectively, in naïve (A,D), vehicle (B,E), and CMP-treated (C,F) mice. Desiccation reduces the amplitude of the derivative compared to naïve; CMP reverses this trend. (G) The transition delta is significantly reduced in the vehicle group compared to naive (#, p = 0.01), which is reversed by CMP 03A (*, p = 0.035). (H) The area under the curve (AUC) is significantly reduced by vehicle compared to naïve (#, p = 0.002); CMP 03A improves this trend compared to vehicle (*, p < 0.001), elevating to naïve levels. Similarly, the area under the curve per transition (I) is significantly reduced in vehicle compared to naïve (#, p = 0.008). CMP 03A improves this compared to vehicle (p = 0.001), once again to naïve levels. Results obtained from imaging as described in Figure 7 and replicated as follows: n = 3 (naïve), 6 (vehicle), and 8 (CMP 03A).