Table 1.
Significant Reactome pathways with associated HitGenes.
| REACTOME PATHWAY | FDR | HITGENES |
|---|---|---|
| ADAPTIVE IMMUNE SYSTEM | 3.06E-14 | TRAC, TRBC1, HLA-DOA, HLA-DOB, LAG3, PRKCB, BTK, BLK, DAPP1, RASGRP2, CD1C, RASGRP1, CD79B, INPP5D, CD19, SLAMF6, ICOS, SH2D1A, NFATC1, PTPRC, CD28, HLA-DRA, CD22, ITK, CD40, PIK3CD, CD3G, CD3E, ITGAL, CD3D, ZAP70, LCK, EVL, WAS, FYB, HLA-DMA, HLA-DMB, KLRG1, CD74, CD247, PDCD1, CLEC2D |
| GENERATION OF SECOND MESSENGER MOLECULES | 1.53E-13 | TRAC, TRBC1, HLA-DRA, ITK, CD3G, CD3E, CD3D, ZAP70, LCK, EVL, WAS, FYB, CD247 |
| TCR SIGNALING | 7.16E-10 | TRAC, TRBC1, INPP5D, PTPRC, HLA-DRA, ITK, CD3G, CD3E, CD3D, ZAP70, LCK, EVL, WAS, FYB, CD247 |
| TRANSLOCATION OF ZAP-70 TO IMMUNOLOGICAL SYNAPSE | 1.02E-09 | TRAC, TRBC1, HLA-DRA, CD3G, CD3E, CD3D, ZAP70, LCK, CD247 |
| PHOSPHORYLATION OF CD3 AND TCR ZETA CHAINS | 1.82E-09 | TRAC, TRBC1, PTPRC, HLA-DRA, CD3G, CD3E, CD3D, LCK, CD247 |
| CYTOKINE SIGNALING IN IMMUNE SYSTEM | 1.82E-09 | TNF, TNFRSF4, GBP5, EBI3, GATA3, INPP5D, TNFRSF9, LCN2, HLA-DRA, CIITA, CD40, PIK3CD, CXCL1, TNFRSF13C, JAK3, FCER2, LCK, LTA, LCP1, LTB, BIRC3, CCL4, IL21R, IL12RB1, GBP4, NOS2, CCL20, BATF, IL2RB, PTPN7 |
| PD-1 SIGNALING | 2.02E-09 | TRAC, TRBC1, HLA-DRA, CD3G, CD3E, CD3D, LCK, CD247, PDCD1 |
| COSTIMULATION BY THE CD28 FAMILY | 2.52E-08 | TRAC,T RBC1, ICOS, CD28, HLA-DRA, CD3G, CD3E, CD3D, LCK, CD247, PDCD1 |
| IMMUNOREGULATORY INTERACTIONS BETWEEN A LYMPHOID AND A NON-LYMPHOID CELL | 3.67E-07 | TRAC, TRBC1, CD1C, CD19, SLAMF6, SH2D1A, CD22, CD40, CD3G, CD3E, ITGAL, CD3D, KLRG1, CD247, CLEC2D |
| SIGNALING BY INTERLEUKINS | 8.50E-06 | TNF, EBI3, GATA3, INPP5D, LCN2, PIK3CD, CXCL1, JAK3, FCER2, LCK, LCP1, CCL4, IL21R, IL12RB1, NOS2, CCL20, BATF, IL2RB, PTPN7 |
| TNF RECEPTOR SUPERFAMILY (TNFSF) MEMBERS MEDIATING NON-CANONICAL NF-KB PATHWAY | 3.16E-05 | CD40, TNFRSF13C, LTA, LTB, BIRC3 |
| DOWNSTREAM TCR SIGNALING | 4.49E-05 | TRAC, TRBC1, INPP5D, HLA-DRA, CD3G, CD3E, CD3D, LCK, CD247 |
| INTERLEUKIN-2 FAMILY SIGNALING | 1.82E-04 | INPP5D, PIK3CD, JAK3, LCK, IL21R, IL2RB |
| TNFR2 NON-CANONICAL NF-KB PATHWAY | 2.65E-04 | TNF, TNFRSF4, TNFRSF9, CD40, TNFRSF13C, LTA, LTB, BIRC3 |
| SIGNALING BY THE B CELL RECEPTOR (BCR) | 3.48E-04 | PRKCB, BTK, BLK, DAPP1, RASGRP1, CD79B, CD19, NFATC1, CD22, PIK3CD |
| CHEMOKINE RECEPTORS BIND CHEMOKINES | 6.22E-04 | CXCL1, CXCL3, CXCR4, CXCR6, CCL4, CCL20 |
| INNATE IMMUNE SYSTEM | 8.28E-04 | C4A, TBC1D10C, BTK, HVCN1, PLD4, RASGRP2, RASGRP1, CD19, LY86, NFATC1, PTPRC, LCN2, ARHGAP9, ITK, CD3G, CXCL1, ITGAL, RAC2, CR1, AIM2, LCK, LTF, BIRC3, WAS, NLRC3, NOS2, CD247 |
| ANTIGEN ACTIVATES B CELL RECEPTOR (BCR) LEADING TO GENERATION OF SECOND MESSENGERS | 1.15E-03 | BTK, BLK, DAPP1, CD79B, CD19, CD22, PIK3CD |
| INTERLEUKIN-10 SIGNALING | 2.18E-03 | TNF, CXCL1, FCER2, CCL4, CCL20 |
| MHC CLASS II ANTIGEN PRESENTATION | 2.18E-03 | HLA-DOA, HLA-DOB, LAG3, HLA-DRA, HLA-DMA, HLA-DMB, CD74 |
| INTERLEUKIN-4 AND INTERLEUKIN-13 SIGNALING | 2.57E-03 | TNF, GATA3, LCN2, JAK3, FCER2, NOS2, BATF |
| INTERLEUKIN RECEPTOR SHC SIGNALING | 2.57E-03 | INPP5D, PIK3CD, JAK3, IL2RB |
| INTERLEUKIN-2 SIGNALING | 3.67E-03 | JAK3, LCK, IL2RB |