FIGURE 4.

Surgical complexity rating. A, Distribution of surgical complexity after neoadjuvant treatment with nivolumab versus nivolumab with ipilimumab. B, Operative time (minutes) for each surgical complexity score after neoadjuvant treatment with nivolumab versus nivolumab with ipilimumab. C, Estimated blood loss (mL) for each surgical complexity score after neoadjuvant treatment with nivolumab versus nivolumab with ipilimumab. D, Percent viable tumor for surgical complexity score after neoadjuvant treatment with nivolumab versus nivolumab with ipilimumab. The green dashed line indicates 10% viable tumor threshold for major pathologic response. The box is drawn from the first quartile to the third quartile with inside line indicating the median value. The whiskers extend from the ends of the box to the minimum and maximum nonoutliers. Outliers are 1.5 times outside the interquartile range above the upper quartile and below the lower quartile. Surgical complexity scale: 1 = easier than normal tissue dissection; 2 = normal tissue dissection; 3 = difficult tissue dissection because of inflammation; and 4 = very complex tissue dissection.