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. 2023 May 30;18(5):e0286364. doi: 10.1371/journal.pone.0286364

Table 2. Patient cardiac and cancer medications according to Her2/ATC treatment status.

AT NAT Total P value
N = 62 (%) N = 54 (%) N = 116 (%)
Cardiac Medications
Beta blocker 32(51.6) 36(66.7) 68(58.6) 0.146
ACEi/ARB 27(43.5) 20(37.0) 47(40.5) 0.603
Statins 27(43.5) 26(48.1) 53(45.7) 0.752
Nitrates 3(4.8) 2(3.7) 5(4.3) 0.888
Cancer therapy
Herceptin/Perjeta 27(43.5) 0(0.0) 27(23.3) < .0001*
ICI 1(1.6) 0(0.0) 1(0.9) 1.000
Anthracycline 52(83.9) 0(0.0) 52(44.8) < .0001*
TKI 6(9.7) 1(1.9) 7(6.0) 0.169
Radiation Therapy 51(82.3) 40(74.1) 91(78.4) 0.399
Other Cancer Therapies
PARP inhibitors 0(0.0) 0(0.0) 0(0.0) 1.000
Anti-Metabolites 9(14.5) 1(1.9) 10(8.6) 0.036*
SERMs/Anti-estrogens 32(51.6) 31(57.4) 63(54.3) 0.663
Platinum Agents 5(8.1) 0(0.0) 5(4.3) 0.094
Topoisomerase Inhibitors 0(0.0) 0(0.0) 0(0.0) 1.000
Proteasome Inhibitors 0(0.0) 3(5.6) 3(2.6) 0.196
Alkylating agents 30(48.4) 0(0.0) 30(25.9) < .0001*
Taxanes 45(72.6) 0(0.0) 45(38.8) < .0001*