Table 2.

Univariate and Multivariate Cox regression analyses.

Variable	Univariate		P value	Multivariate		P value
	HR	95%CI		HR	95%CI
Age
17-30	Reference			Reference
30-40	0.67	0.40-1.10	0.11	0.78	0.47-1.30	0.35
40-50	0.55	0.34-0.88	<0.01	0.71	0.44-1.14	0.16
Race
Black	Reference			Reference
White	0.63	0.45-0.90	<0.01	0.67	0.74-1.42	0.13
Other	0.95	0.63-1.43	0.82	1	0.66-1.51	0.87
Sex
F	Reference			Reference
M	1.53	1.23-1.90	<0.01	1.45	1.16-1.82	<0.01
Pathology
Adenocarcinoma	Reference			Reference
Mucinous and signet ring cell carcinoma	2.09	1.47-2.99	<0.01	1.49	1.03-2.15	<0.01
Others	2.05	1.36-3.09	<0.01	1.47	0.96-2.25	0.07
Grade
I	Reference			Reference
II	1.81	0.99-3.32	0.07	1.69	0.92-3.12	0.08
III	4.12	2.19-7.72	<0.01	2.66	1.40-5.05	<0.01
IV	3.51	1.52-8.01	<0.01	2.62	1.12-6.12	<0.01
Stages T a
T1	Reference			Reference
T2	4.51	2.14-6.38	<0.01	5.37	0.69-3.12	0.10
T3	2.65	1.94-3.71	<0.01	3.14	1.57-4.65	<0.01
T4	5.76	3.61-6.82	<0.01	6.77	4.83-8.15	<0.01
Stages N a
N0	Reference			Reference
N1	1.53	1.15-2.09	<0.01	1	0.68-1.47	0.98
N2	2.97	2.21-3.99	<0.01	1.01	0.65-1.59	0.93
Tumor size
0-5	Reference			Reference
5-10	1.27	1.02-1.57	<0.01	1.08	0.87-1.36	0.45
>10	2.2	1.43-3.38	<0.01	0.98	0.60-1.58	0.94
Number
1	Reference			Reference
>1	1.33	0.91-1.95	0.13	1.44	0.95-2.13	0.06
LNR
0	Reference			Reference
0-0.20	1.53	1.17-1.99	<0.01	1.75	1.22-2.50	<0.01
0.2-0.4	3.19	2.38-4.28	<0.01	3.28	2.18-4.91	<0.01
>0.4	4.31	3.18-5.84	<0.01	3.57	2.32-5.48	<0.01
CEA
Positive	Reference			Reference
Negative	0.52	0.42-0.64	<0.01	0.65	0.52-0.81	<0.01
Radiation
No	Reference			Reference
Yes	0.59	0.45-0.78	<0.01	0.56	0.41-0.77	<0.01
Chemotherapy
Yes	Reference			Reference
No	0.67	0.44-1.02	0.06	1.32	0.83-2.10	0.23

^aAJCC (TNM) Stages: The eighth edition AJCC (TNM) staging system.