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. 2022 Jun 2;5(2):39–43. doi: 10.36401/JQSH-21-17

Table 4.

Examples of framework used to write research questions

Acronym
Elements of the framework
PICO Population, Intervention, Comparison, Outcome
PICOS Patient population or problem, Intervention (treatment or test), Comparison (group or treatment), Outcomes, and Setting or study type
PICOT Patient population of interest, Intervention or issue of interest, Comparison with another intervention or issue, Outcome of interest and Time frame
PESICO Person, Environment, Stakeholders, Intervention, Comparison, Outcomes,
SPICE Setting, Perspective, Intervention or Exposure or Interest, Comparison, Evaluation
SPIDER Sample, Phenomenon of Interest, Design, Evaluation, Research Type

Content based on Fandino,[1] Thabane et al,[3] Cooke et al,[9] and Cañón and Buitrago-Gómez.[10]