Table 3.

Univariate and Multivariable Cox Regression Models for risk factors for Day 60 severe AKI.

Covariate	Categories	HR (95% CI)	P	aHR (95% CI)	P
Age (years) – per one-year increase
		1.0 (0.99-1.02)	.53	1.00 (0.98-1.02)	.95
Sex
	Female	1		1
	Male	0.58 (0.36-0.93)	.02	0.66 (0.37-1.16)	.15
Conditioning regimen
	MAC	1
	NAC	0.53 (0.21-1.32)	.17
Baseline creatinine – per 1 Unit increase
		0.9 (0.37-2.18)	.82
Acute GVHD‡
	Grade 0-1	1		1
	Grade 2-4	0.54 (0.3-0.96)	.04	0.53 (0.26-1.10)	.09
Acute Skin GVHD‡
	Grade 0-1	1
	Grade 2-4	0.65 (0.36-1.18)	.16
Acute Liver GVHD‡
	Grade 0-1	1
	Grade 2-4	2.73 (1.17-6.4)	.02
Acute Gut GVHD‡
	Grade 0-1	1
	Grade 2-4	0.65 (0.23-1.8)	0.4
Systemic steroid administration‡
		0.36 (0.18-0.72)	.004
Vancomycin administration‡
		0.23 (0.06-0.95)	.04
Gentamycin administration‡
		2.1 (0.5-8.85)	.31
Cyclosporine¶ – per 100 Unit increase
		1.19 (1.03-1.37)	.02	1.18 (1.02-1.37)	.02
Tacrolimus¶ – per 1 Unit increase
		1.21 (0.9-1.62)	.2
Bilirubin¶ – per 1 Unit increase
		1.3 (1.18-1.43)	<.0001	1.23 (1.13-1.34)	<.0001
Log(CMV) ¶ – per 1 Unit increase
		1.37 (1.07-1.76)	.01	1.35 (0.98-1.85)	.06
Log(BK) ¶ – per 1 Unit increase
		0.58 (0.32-1.05)	.07

AKI, acute kidney injury; HR, Hazard Ratio; aHR, adjusted HR; NAC, non-myeloablative conditioning; MAC, myeloablative conditioning; GVHD, graft versus host disease; CMV, cytomegalovirus.

Amphotericin administration was not considered in this model due to the limited number of patients.

^‡These variables were modeled as time-dependent indicator variables.

^¶These variables were modeled as time- dependent continuous linear variables.