Table 3.
Overview of studies reporting differential KLB mRNA expression or KLB protein levels.
| Species | Condition | Tissue | mRNA/protein | Effect | Study |
|---|---|---|---|---|---|
| Mus musculus | Obesity | Adipose tissue | mRNA | ↓ | Fischer, 2010. (36) |
| Mus musculus | Obesity | Adipose tissue | mRNA | ↓ | Hale, 2012 (37). |
| Mus musculus | HFD | Liver | mRNA & protein | ↓ | Fu, 2012 (38). |
| Mus musculus | HFD | Adipose tissue | mRNA & protein | ↓ | Diaz-Delfin, 2012. (39) |
| Mus musculus | JNK-/- mice | Adipose tissue | mRNA & protein | ↑ | Diaz-Delfin, 2012. (39) |
| Mus musculus | Genetic obesity (db/db) |
Islets | mRNA & protein | ↓ | So, 2013 (40). |
| Macaca Mulatta | HFD | Pancreas | mRNA | ↓ | Nygaard, 2014. (41) |
| Macaca Mulatta | HFD | Adipose tissue | mRNA | ↓ | Nygaard, 2014. (41) |
| Mus musculus | HFD | Liver | Protein | ↑ | Dong, 2015 (42). |
| Mus musculus | Genetic obesity (ob/ob) |
Liver | Protein | ↑ | Dong, 2015 (42). |
| Homo sapiens | NAFLD | Liver | Protein | ↑ | Dong, 2015 (42). |
| Mus musculus | LPS | Liver | mRNA & protein | ↓ | Zhao, 2015 (43). |
| Mus musculus | IL-1β | Liver | mRNA & protein | ↓ | Zhao, 2015 (43). |
| Homo sapiens | Obesity | Liver | mRNA | ↑ | Gallego-Escuredo, 2015 (44). |
| Homo sapiens | Obesity | Adipose tissue | mRNA & protein | ↓ | Gallego-Escuredo, 2015 (44). |
|
Mirounga
angustirostris |
Fasting | Adipose tissue | mRNA | ↓ | Suzuki, 2015 (45). |
| Mus musculus | HFD | Adipose tissue | mRNA & protein | ↓ | Markan, 2017. (46) |
| Homo sapiens | Fibrosis | Liver | mRNA | ↓ | Lee, 2018 (47). |
| Homo sapiens | Fasting | Adipose tissue | mRNA | ↓ | Nygaard, 2018. (48) |
| Homo sapiens | NASH | Liver | Protein | ↓ | Dongiovanni, 2020 (20). |
| Sus scrofa domesticus | Fat, fructose and cholesterol diet |
Liver | mRNA | ↓ | Cirera, 2020 (49). |
JNK, c-Jun N-terminal kinase; NAFLD, non-alcoholic fatty liver disease; LPS, lipopolysaccharide; IL-1β, interleukin 1β; NASH, non-alcoholic steatohepatitis; HFD, high-fat diet.