Table 1. Simulation specifications.
The definition and values of the parameters used in the presented simulations are tabulated.
| Parameters | Description | Values |
|---|---|---|
| Specification of catAb | ||
| K D | Dissociation constant of antibody | 10 nM |
| (KD)catenator | Dissociation constant of catenator | 10 nM-10 mM |
| [catAb] | Antibody concentration | 1 nM |
| l | Length of the flexible linker | 6 nm |
| c | Length of the catenator | 2 nm |
| L | Reach length (l+c/2) | 7 nm |
| Specification of the target surface | ||
| Ntotal_binding_sites (in Figures 3 and 4) |
Number of antibody-binding sites | 98–102 |
| Connectivity number (in Figures 3 and 4) |
Number of possible catenation | 3 (Hexagonal) 4 (Square) 6 (Triangular) |
| d (in Figures 3 and 4) | Distance between adjacent binding sites | 12 nm |
| Lsurface (in Figure 4) | Surface area of the target surface | 40 nm2 |
| Binding site density (in Figure 4) |
Surface density of the binding sites | 1.47–11.76 (per 7x7 nm2) |
| Specification of simulation | ||
| Updates/MCMC step | Number of updates in one MCMC step | 30,000–100,000 |
| Sampling size | Number of sampling for a parameter set | 1024 |