Table 3.
Five-Year Total, Annual Average Total a, and Average Annual Age-Adjusted Incidence Rates b with 95% Confidence Intervals for All Brain and Other Central Nervous System Tumors by Major Histopathology Groupings, Histopathology, Behavior, and Sex, 2015-2019 NAACCR CiNA
| Histopathology | Total | Male | Female | ||||||
|---|---|---|---|---|---|---|---|---|---|
| 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | 5-Year Total | Annual Average | Rate (95% CI) | |
| Diffuse astrocytic and oligodendroglial tumors | 91,847 | 18,369 | 4.50 (4.47-4.53) | 52,901 | 10,580 | 5.49 (5.44-5.54) | 38,946 | 7,789 | 3.64 (3.60-3.68) |
| Diffuse astrocytoma | 9,687 | 1,937 | 0.52 (0.51-0.53) | 5,456 | 1,091 | 0.60 (0.59-0.62) | 4,231 | 846 | 0.45 (0.43-0.46) |
| Anaplastic astrocytoma | 7,526 | 1,505 | 0.40 (0.39-0.41) | 4,120 | 824 | 0.45 (0.44-0.47) | 3,406 | 681 | 0.35 (0.34-0.36) |
| Glioblastoma | 67,827 | 13,565 | 3.20 (3.18-3.22) | 39,549 | 7,910 | 4.00 (3.96-4.04) | 28,278 | 5,656 | 2.50 (2.48-2.54) |
| Oligodendroglioma | 4,048 | 810 | 0.23 (0.23-0.24) | 2,247 | 449 | 0.26 (0.25-0.27) | 1,801 | 360 | 0.20 (0.20-0.21) |
| Anaplastic oligodendroglioma | 2,164 | 433 | 0.12 (0.11-0.12) | 1,209 | 242 | 0.14 (0.13-0.14) | 955 | 191 | 0.10 (0.09-0.11) |
| Oligoastrocytic tumors | 595 | 119 | 0.03 (0.03-0.04) | 320 | 64 | 0.04 (0.03-0.04) | 275 | 55 | 0.03 (0.03-0.03) |
| Other astrocytic tumors | 6,701 | 1,340 | 0.42 (0.41-0.43) | 3,545 | 709 | 0.44 (0.42-0.45) | 3,156 | 631 | 0.40 (0.39-0.42) |
| Pilocytic astrocytoma | 5,706 | 1,141 | 0.36 (0.35-0.37) | 3,003 | 601 | 0.37 (0.36-0.39) | 2,703 | 541 | 0.35 (0.33-0.36) |
| Unique astrocytoma variants | 995 | 199 | 0.06 (0.06-0.06) | 542 | 108 | 0.07 (0.06-0.07) | 453 | 91 | 0.06 (0.05-0.06) |
| Malignant | 573 | 115 | 0.03 (0.03-0.04) | 296 | 59 | 0.04 (0.03-0.04) | 277 | 55 | 0.03 (0.03-0.04) |
| Nonmalignant | 422 | 84 | 0.03 (0.02-0.03) | 246 | 49 | 0.03 (0.03-0.03) | 176 | 35 | 0.02 (0.02-0.03) |
| Ependymal tumors | 7,460 | 1,492 | 0.42 (0.41-0.43) | 4,302 | 860 | 0.49 (0.47-0.50) | 3,158 | 632 | 0.35 (0.34-0.36) |
| Malignant | 4,110 | 822 | 0.23 (0.23-0.24) | 2,250 | 450 | 0.26 (0.25-0.27) | 1,860 | 372 | 0.21 (0.20-0.22) |
| Nonmalignant | 3,350 | 670 | 0.18 (0.18-0.19) | 2,052 | 410 | 0.23 (0.22-0.24) | 1,298 | 260 | 0.14 (0.13-0.15) |
| Other gliomas | 9,672 | 1,934 | 0.55 (0.54-0.56) | 4,909 | 982 | 0.57 (0.56-0.59) | 4,763 | 953 | 0.53 (0.51-0.54) |
| Glioma malignant, NOS | 9,561 | 1,912 | 0.54 (0.53-0.55) | 4,865 | 973 | 0.57 (0.55-0.58) | 4,696 | 939 | 0.52 (0.50-0.54) |
| Other neuroepithelial tumors | 111 | 22 | 0.01 (0.01-0.01) | 44 | 9 | 0.01 (0.00-0.01) | 67 | 13 | 0.01 (0.01-0.01) |
| Neuronal and mixed neuronal-glial tumors | 5,805 | 1,161 | 0.34 (0.33-0.35) | 3,154 | 631 | 0.37 (0.36-0.38) | 2,651 | 530 | 0.31 (0.30-0.32) |
| Malignant | 1,066 | 213 | 0.06 (0.05-0.06) | 588 | 118 | 0.06 (0.06-0.07) | 478 | 96 | 0.05 (0.05-0.05) |
| Nonmalignant | 4,739 | 948 | 0.28 (0.28-0.29) | 2,566 | 513 | 0.31 (0.29-0.32) | 2,173 | 435 | 0.26 (0.25-0.27) |
| Choroid plexus tumors | 880 | 176 | 0.05 (0.05-0.06) | 441 | 88 | 0.05 (0.05-0.06) | 439 | 88 | 0.05 (0.05-0.06) |
| Malignant | 125 | 25 | 0.01 (0.01-0.01) | 74 | 15 | 0.01 (0.01-0.01) | 51 | 10 | 0.01 (0.00-0.01) |
| Nonmalignant | 755 | 151 | 0.04 (0.04-0.05) | 367 | 73 | 0.04 (0.04-0.05) | 388 | 78 | 0.04 (0.04-0.05) |
| Tumors of the pineal region | d | 167 | 0.05 (0.04-0.05) | 352 | 70 | 0.04 (0.04-0.05) | 484 | 97 | 0.06 (0.05-0.06) |
| Malignant | 508 | 102 | 0.03 (0.03-0.03) | 243 | 49 | 0.03 (0.02-0.03) | 265 | 53 | 0.03 (0.03-0.04) |
| Nonmalignant | 328 | 66 | 0.02 (0.02-0.02) | 109 | 22 | 0.01 (0.01-0.01) | 219 | 44 | 0.02 (0.02-0.03) |
| Embryonal tumors | 3,453 | 691 | 0.22 (0.21-0.23) | 2,086 | 417 | 0.26 (0.25-0.27) | 1,367 | 273 | 0.18 (0.17-0.19) |
| Tumors of cranial and paraspinal nerves | 39,749 | 7,950 | 2.02 (2.00-2.04) | 19,099 | 3,820 | 2.02 (1.99-2.05) | 20,650 | 4,130 | 2.03 (2.00-2.06) |
| Nerve sheath tumors | 39,714 | 7,943 | 2.02 (2.00-2.04) | 19,078 | 3,816 | 2.01 (1.99-2.04) | 20,636 | 4,127 | 2.03 (2.00-2.05) |
| Malignant | 233 | 47 | 0.01 (0.01-0.01) | 118 | 24 | 0.01 (0.01-0.02) | 115 | 23 | 0.01 (0.01-0.01) |
| Nonmalignant | 39,481 | 7,896 | 2.00 (1.98-2.02) | 18,960 | 3,792 | 2.00 (1.97-2.03) | 20,521 | 4,104 | 2.01 (1.99-2.04) |
| Other tumors of cranial and paraspinal nerves | 35 | 7 | 0.00 (0.00-0.00) | 21 | 4 | 0.00 (0.00-0.00) | 14 | 3 | 0.00 (0.00-0.00) |
| Tumors of meninges | 193,788 | 38,758 | 9.48 (9.44-9.52) | 54,414 | 10,883 | 5.80 (5.76-5.86) | 139,374 | 27,875 | 12.76 (12.69-12.83) |
| Meningioma | 186,524 | 37,305 | 9.09 (9.05-9.13) | 50,719 | 10,144 | 5.40 (5.35-5.45) | 135,805 | 27,161 | 12.38 (12.31-12.45) |
| Malignant | 1,768 | 354 | 0.09 (0.08-0.09) | 823 | 165 | 0.09 (0.08-0.09) | 945 | 189 | 0.09 (0.08-0.09) |
| Nonmalignant | 184,756 | 36,951 | 9.00 (8.96-9.04) | 49,896 | 9,979 | 5.31 (5.26-5.36) | 134,860 | 26,972 | 12.29 (12.22-12.36) |
| Mesenchymal tumors | 7,103 | 1,421 | 0.38 (0.37-0.39) | 3,603 | 721 | 0.40 (0.38-0.41) | 3,500 | 700 | 0.37 (0.36-0.39) |
| Malignant | 851 | 170 | 0.05 (0.04-0.05) | 452 | 90 | 0.05 (0.05-0.06) | 399 | 80 | 0.04 (0.04-0.05) |
| Nonmalignant | 6,252 | 1,250 | 0.34 (0.33-0.35) | 3,151 | 630 | 0.35 (0.33-0.36) | 3,101 | 620 | 0.33 (0.32-0.34) |
| Primary melanocytic lesions | 161 | 32 | 0.01 (0.01-0.01) | 92 | 18 | 0.01 0.01-0.01) | 69 | 14 | 0.01 (0.01-0.01) |
| Lymphomas and hematopoietic neoplasms | 9,259 | 1,852 | 0.44 (0.43-0.45) | 4,764 | 953 | 0.49 (0.48-0.51) | 4,495 | 899 | 0.40 (0.39-0.41) |
| Lymphoma | 9,210 | 1,842 | 0.44 (0.43-0.45) | 4,736 | 947 | 0.49 (0.48-0.50) | 4,474 | 895 | 0.40 (0.39-0.41) |
| Other hematopoietic neoplasms | 49 | 10 | 0.00 (0.00-0.00) | 28 | 6 | 0.00 (0.00-0.00) | 21 | 4 | 0.00 (0.00-0.00) |
| Germ cell tumors | 1,769 | 354 | 0.11 (0.10-0.11) | 1,226 | 245 | 0.15 (0.14-0.16) | 543 | 109 | 0.07 (0.06-0.07) |
| Malignant | 1,229 | 246 | 0.08 (0.07-0.08) | 938 | 188 | 0.11 (0.11-0.12) | 291 | 58 | 0.04 (0.03-0.04) |
| Nonmalignant | 540 | 108 | 0.03 (0.03-0.04) | 288 | 58 | 0.03 (0.03-0.04) | 252 | 50 | 0.03 (0.03-0.03) |
| Tumors of sellar region | 83,392 | 16,678 | 4.47 (4.44-4.50) | 37,348 | 7,470 | 4.01 (3.97-4.05) | 46,044 | 9,209 | 5.01 (4.96-5.06) |
| Tumors of the pituitary | 80,004 | 16,001 | 4.28 (4.25-4.31) | 35,593 | 7,119 | 3.81 (3.77-3.86) | 44,411 | 8,882 | 4.83 (4.78-4.88) |
| Malignant | 118 | 24 | 0.01 (0.00-0.01) | ||||||
| Nonmalignant | 79,886 | 15,977 | 4.28 (4.25-4.31) | ||||||
| Craniopharyngioma | 3,388 | 678 | 0.19 (0.18-0.19) | 1,755 | 351 | 0.20 (0.19-0.21) | 1,633 | 327 | 0.18 (0.17-0.19) |
| Unclassified tumors | 26,973 | 5,395 | 1.37 (1.35-1.39) | 12,213 | 2,443 | 1.36 (1.34-1.39) | 14,760 | 2,952 | 1.39 (1.36-1.41) |
| Hemangioma | 4,377 | 875 | 0.24 (0.23-0.24) | 2,047 | 409 | 0.23 (0.22-0.24) | 2,330 | 466 | 0.25 (0.24-0.26) |
| Neoplasm, unspecified | 22,240 | 4,448 | 1.11 (1.10-1.13) | 9,971 | 1,994 | 1.11 (1.09-1.13) | 12,269 | 2,454 | 1.12 (1.10-1.14) |
| Malignant | 7,584 | 1,517 | 0.37 (0.36-0.38) | 3,693 | 739 | 0.41 (0.40-0.43) | 3,891 | 778 | 0.33 (0.32-0.34) |
| Nonmalignant | 14,656 | 2,931 | 0.74 (0.73-0.76) | 6,278 | 1,256 | 0.70 (0.68-0.71) | 8,378 | 1,676 | 0.79 (0.77-0.81) |
| All other | 206 | 41 | 0.01 (0.01-0.01) | 126 | 25 | 0.01 (0.01-0.02) | 80 | 16 | 0.01 (0.01-0.01) |
| Brain/CNS not categorized c | 150 | 30 | 0.01 (0.01-0.01) | 69 | 14 | 0.01 (0.01-0.01) | 81 | 16 | 0.01 (0.01-0.01) |
| Total d | 481,650 | 96,330 | 24.44 (24.37-24.51) | 200,781 | 40,156 | 21.55 (21.45-21.64) | 280,869 | 56,174 | 27.16 (27.06-27.27) |
| Malignant | 137,617 | 27,523 | 7.00 (6.96-7.04) | 76,982 | 15,396 | 8.23 (8.18-8.29) | 60,635 | 12,127 | 5.90 (5.85-5.95) |
| Nonmalignant | 344,033 | 68,807 | 17.44 (17.38-17.50) | 123,799 | 24,760 | 13.31 (13.24-13.39) | 220,234 | 44,047 | 21.26 (21.17-21.35) |
ICD-O-3, International Classification of Diseases for Oncology, 3rd edition; NOS, not otherwise specified.
a
Annual average cases are calculated by dividing the five-year total by five
b
Rates are per 100,000 and are age-adjusted to the 2000 US standard population.
c
Includes ICD-O-3 codes fitting site criteria that are not included in CBTRUS histopathology classification
d
Refers to all brain tumors including histopathologies not presented in this table.
Counts and rates are not presented when fewer than 16 cases were reported for the specific category. The suppressed cases are included in the counts and rates for totals.