Table 2.
Comparison of MMSE, MoCA, HAM-D and HAM-A scores and score changes between the two study groups.
| Clinical scores | Famotidine group (N = 25), mean (SD) | Placebo group (N = 25), mean (SD) | Mean difference (95% CI) | t-value | p-value |
|---|---|---|---|---|---|
| MMSE score at baseline | 20.48 (2.18) | 20.32 (1.77) | 0.16 (−0.97 to 1.29) | 0.285 | 0.777 |
| MMSE score at week 6 | 23.04 (2.03) | 21.76 (1.45) | 1.28 (0.28 to 2.28) | 2.564 | 0.014 |
| MMSE score at week 12 | 25.44 (2) | 23 (1.32) | 2.44 (1.47 to 3.41) | 5.085 | <0.001 |
| Changes in MMSE score from baseline to week 6 | 2.56 (2.18) | 1.44 (1.16) | 1.12 (0.13 to 2.11) | 2.268 | 0.028 |
| Changes in MMSE score from baseline to week 12 | 4.96 (2.34) | 2.68 (1.52) | 2.28 (1.16 to 3.4) | 4.091 | <0.001 |
| MoCA score at baseline | 20.08 (1.58) | 20.36 (1.6) | −0.28 (−1.19 to 0.63) | −0.622 | 0.537 |
| MoCA score at week 6 | 23.48 (1.98) | 21.68 (1.41) | 1.8 (0.82 to 2.78) | 3.704 | 0.001 |
| MoCA score at week 12 | 25.84 (1.55) | 23.28 (1.51) | 2.56 (1.69 to 3.43) | 5.915 | <0.001 |
| Changes in MoCA score from baseline to week 6 | 3.4 (2.06) | 1.32 (1.25) | 2.08 (1.11 to 3.05) | 4.315 | <0.001 |
| Changes in MoCA score from baseline to week 12 | 5.76 (1.74) | 2.92 (1.44) | 2.84 (1.93 to 3.75) | 6.288 | <0.001 |
| Ham-D score at baseline | 12.2 (2.04) | 11.6 (2.08) | 0.6 (−0.57 to 1.77) | 1.029 | 0.309 |
| Ham-D score at week 6 | 10.6 (1.29) | 10.76 (1.69) | −0.16 (−1.02 to 0.7) | −0.376 | 0.708 |
| Ham-D score at week 12 | 10.04 (1.21) | 10.36 (1.38) | −0.32 (−1.06 to 0.42) | −0.872 | 0.387 |
| Changes in HAM-D score from baseline to week 6 | −1.6 (1.19) | −0.84 (0.69) | −0.76 (−1.32 to −0.2) | −2.764 | 0.009 |
| Changes in HAM-D score from baseline to week 12 | −2.16 (1.46) | −1.24 (1.23) | −0.92 (−1.69 to −0.15) | −2.403 | 0.020 |
| Ham-A score at baseline | 10.2 (1.15) | 10.3 (1.18) | −0.12 (−0.78 to 0.54) | −0.363 | 0.718 |
| Ham-A score at week 6 | 9.8 (0.97) | 10.2 (1.13) | −0.40 (−1.00 to 0.2) | −1.337 | 0.187 |
| Ham-A score at week 12 | 9.4 (1.04) | 10.1 (1.05) | −0.72 (−1.13 to −0.12) | −2.431 | 0.019 |
| Changes in HAM-A score from baseline to week 6 | −0.32 (0.62) | −0.04 (0.2) | −0.28 (−0.54 to −0.01) | −2.127 | 0.042 |
| Changes in HAM-A score from baseline to week 12 | −0.8 (1.19) | −0.2 (0.5) | −0.60 (−1.12 to −0.07) | −2.324 | 0.027 |
p-value of <0.05 was considered statistically significant. (Shown in bold).
Abbreviations: MMSE: Mini-Mental State Examination, MoCA: Montreal Cognitive Assessment, HAM—D: Hamilton Depression Rating Scale, HAM-A: Hamilton Anxiety Rating Scale.