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. 2023 Feb 9;19(6):731–739. doi: 10.1038/s41589-023-01265-x

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 3 — Mice doubly hemizygous for CAG-LSL-Antares reporter and Vglut2-IRES-cre driver were injected i.p. with 1.3 µmol substrate with 10 mg P-407. a, Comparison between 6 and Fz analogues with fluorination on C6 and C8 ring rings. b, Comparison between 6 and 10, a Fz analogue with a methylated furan ring. In a and b: Left, representative images with peak bioluminescence; right, bioluminescence intensity in the brain over time; data are presented as mean values ± SEM with n = 5 mice in each group. c, Representative photos of 4.2 µmol 10 suspended in a formulation with P-407 indicating incomplete solubilization. The experiment was performed twice with similar results.