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. 2023 May 25;5(5):789–803. doi: 10.1038/s42255-023-00804-z

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Extended Data Fig. 2 — (A) UIH-induced core body temperature change (max ΔT_core) and metabolic rate change (max ΔVO₂) in female (pink) and male (blue) mice. In the left plot, n = 6 male mice in both US⁺ and US⁻ groups and n = 7 female mice in US⁺ and 8 female mice in US⁻ group. In the right plot, n = 5 mice in all groups. (B) Temporal correlation of VO₂ and T_core induced by ultrasound stimulation. US sonication is indicated by the pink bar. (C) Comparison of VO₂ and T_core onset time. N = 7 mice. (D) Quantification of the duration of the hypothermic state. N = 7 mice. (E) Quantification of the rewarming time (from the lowest T_core to 34 °C) in groups receiving single US stimulation and receiving long-duration feedback-controlled ultrasound stimulation. N = 7 mice for the single US stimulation group and 4 mice for the feedback-controlled ultrasound stimulation group. Error bars denote s.e.m. Each dot represents one mouse. P values were calculated using an unpaired two-tailed t-test in (A and E) and a paired two-tailed t-test in C.

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