Table 2.

Summary of Findings for the Overall Risk of Mortality in the TXA vs. Placebo

Outcomes	No of participants (studies) Follow-up	Certainty of the evidence (GRADE)	Relative effect (95% CI)	Anticipated absolute effects
				Risk with placebo	Risk difference with TXA
Mortality 24 h	21,030 (2 RCTs)	⨁⨁⨁⨁ High	RR 0.83 (0.74 to 0.95)	48 per 1.000	8 fewer per 1.000 (13 fewer to 2 fewer)
Mortality 1 month	34,882 (5 RCTs)	⨁⨁⨁⨁ High	RR 0.93 (0.88 to 0.97)	165 per 1.000	12 fewer per 1.000 (20 fewer to 5 fewer)
*The risk in the intervention group (and its 95% confidence interval) is based on the assumed risk in the comparison group and the relative effect of the intervention (and its 95% CI) CI: confidence interval; MD: mean difference; RR: risk ratio
GRADE Working Group grades of evidence High certainty: we are very confident that the true effect lies close to that of the estimate of the effect Moderate certainty: we are moderately confident in the effect estimate: the true effect is likely to be close to the estimate of the effect, but there is a possibility that it is substantially different Low certainty: our confidence in the effect estimate is limited: the true effect may be substantially different from the estimate of the effect Very low certainty: we have very little confidence in the effect estimate: the true effect is likely to be substantially different from the estimate of effect