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. 2023 Mar 6;31(3):1361–1372. doi: 10.1007/s10787-023-01156-6

Fig. 5.

Fig. 5

Effect of protocatechuic acid on FoxO-1 and Nrf-2 gene expression. The effect of treatment with protocatechuic acid (50, 100 mg/kg; p.o.) once daily for 10 consecutive days after cyclophosphamide (200 mg/kg; i.p.) single dose on a FoxO-1 b Nrf-2 gene expression. The data were expressed as mean ± SD, (n = 8). Statistical analysis was carried out by one-way ANOVA followed by Tukey HSD test for multiple comparisons. aSignificantly different from normal control. bSignificantly different from cyclophosphamide control. cSignificantly different from cyclophosphamide + protocatechuic acid 50 mg/kg at P < 0.05