T. marneffei infection in humans remains neglected owing to the lack of competent knowledge of disease performance and prognosis.

We systematically analyzed the clinical characteristics, prognostic factors, and survival outcomes of 241 patients infected with T. marneffei and compared the differences between individuals who were HIV positive and HIV negative.

Clinical features of T. marneffei differ in patients who are HIV positive and HIV negative.

Patients who are HIV negative with T. marneffei infection have a higher neutrophil count, more organ damage, and present a higher mortality.