Table 1.

CDI case definitions

Main case definition	Broad case definition	Strict case definition
Main inpatient diagnosis with ICD-10-GM code A04.7- and/or secondary inpatient diagnosis with ICD-10-GM code A04.7- and/or verified outpatient diagnosis with ICD-10-GM code A04.7- and a prescription of either metronidazole (ATC code J01XD01), vancomycin (ATC code J01XA01), or fidaxomicin (ATC code A07AA12) in the same quarter	Main inpatient diagnosis with ICD-10-GM code A04.7- and/or secondary inpatient diagnosis with ICD-10-GM code A04.7- and/or verified outpatient diagnosis with ICD-10-GM code A04.7-	Main inpatient diagnosis with ICD-10-GM code A04.7- and/or secondary inpatient diagnosis with ICD-10-GM code A04.7- and/or Verified outpatient diagnosis with ICD-10-GM code A04.7- and a prescription of either metronidazole (ATC code J01XD01), vancomycin (ATC code J01XA01), or fidaxomicin (ATC code A07AA12) in the same quarter and a laboratory test for confirmation of CDI (with EBM code 32151, 32700, 32707, 32722, or 32723) in the same quarter

ATC Anatomical Therapeutic Chemical Classification, CDI Clostridioides difficile infection, EBM German physician fee schedule or Einheitlicher Bewertungsmaßstab, ICD-10-GM International Classification of Diseases, 10th Revision, German Modification