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. 2023 May 30;8:27. doi: 10.1038/s41536-023-00301-7

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© The Author(s) 2023

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — a Asymmetry index of forelimbs in the cylinder test (F_2,32 = 50.952, ***P < 0.001. ***P < 0.001, NIM/stroke vs sham or NIM/stroke vs organoids/stroke). b Left-foot faults relative to total steps taken in the grid-walking test (F_2,32 = 317.196, ***P < 0.001. ***P < 0.001, NIM/stroke vs sham or NIM/stroke vs organoids/stroke). c Latency to touch the sticky dot on left paw in the adhesive-removal test (F_2,32 = 27.875, ***P < 0.001. ***P < 0.001, sham vs NIM/stroke; **P = 0.002, NIM/stroke vs organoids/stroke). d Latency to remove the sticky dot on left paw in the adhesive-removal test (F_2,32 = 47.683, ***P < 0.001. ^***P < 0.001, NIM/stroke vs sham or NIM/stroke vs organoids/stroke). e Design of the experiments for f–k. f Image showing mCherry-positive cells in the infarct core (left, scale bar, 50 μm), high magnification images from a selected area in the leftward image (middle, scale bar, 5 μm) and bar graph showing ratio of mCherry⁺/HN⁺ cells to HN⁺ cells (right). n = 6 animals. g In the neurons expressing hM4Di-mCherry, bath application of CNO completely abolished cell discharge of action potentials and this effect was reversed after CNO washout. h Asymmetry index of forelimbs in the cylinder test (F_3,45 = 15.679, ***P < 0.001. *P = 0.014, ***P < 0.001). i Left-foot faults relative to total steps taken in the grid-walking test (F_3,45 = 189.858, ***P < 0.001. ***P < 0.001). j Touch latency (F_3,45 = 0.062, P = 0.062. P > 0.05, between groups) in the adhesive-removal test. k Remove latency (F_3,45 = 9.790, ***P < 0.001. *P = 0.033, ***P < 0.001) in the adhesive-removal test. NIM neural induction medium, HN Human Nuclei. In a–d, f and h–k, data were presented as mean ± standard deviation.