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. 2023 Jan 3;30(6):1758–1769. doi: 10.1007/s43032-022-01162-z

Table 2.

Common variations present in MCT8 and its impact on TH levels

Transporter rs-number Location Gene Change Impact on TH levels References
MCT8 rs5937843 Intron 5 Xq13.2 T > G

Hemizygous male carriers;

• Positive correlation with TSH

• Lower fT4 concentrations

• Inverse relations with total T4 and rT3 levels

 85
rs6647476 Exon1-missense Xq13.2 Ser107Pro (T > A, C)

Hemizygous male carriers;

• Lower levels of fT3

 85