Table 1.
Changes and the inhibition percentage in rats paw thickness in carrageenan-induced inflammation
| Groups | Dose (mg/kg) | Change in paw thickness mm (hours post treatment) | ||||
|---|---|---|---|---|---|---|
| 1st | 2nd | 3rd | 4th | 5th | ||
| Saline | – | 2.28 ± 0.27a | 2.54 ± 0.39a | 3.59 ± 0.43a | 3.22 ± 0.29a | 3.11 ± 0.68a |
| Control positive diclofenac sodium | 10 | 1.32 ± 0.26bc (38.66) |
1.29 ± 0.26 cd (55.71) |
1.31 ± 0.19ef (61.78) |
1.36 ± 0.23d (60.51) |
1.22 ± 0.28c (63.81) |
| OLE | 400 |
1.58 ± 0.17 bc (27.66) |
1.90 ± 0.12abc (25.38) |
2.28 ± 0.12 cd (32.46) |
2.29 ± 0.06bc (32.37) |
1.78 ± 0.17bc (46.99) |
| 200 |
1.60 ± 0.23abc (16.71) |
2.21 ± 0.42ab (14.97) |
2.69 ± 0.24bc (19.99) |
2.615 ± 0.13bc (25.92) |
2.045 ± 0.37bc (42.31) |
|
| 100 |
2.00 ± 0.17ab (4.58) |
2.57 ± 0.42a (1.90) |
3.07 ± 0.24ab (8.19) |
2.88 ± 0.27ab (16.20) |
2.17 ± 0.23ab (36.99) |
|
Each value is the mean SEM for 6 mice. Different letters within the count column mean statistical significance at (P < 0.05)
The percentage of inhibition values are given in parentheses