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. 2022 Dec 6;30(6):1841–1853. doi: 10.1007/s43032-022-01130-7

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© The Author(s) 2022

Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Identification and characteristics of CR-DEGs. a The Venn diagram showing the intersection of DEGs and cuproptosis-related genes. b The heat map of CR-DEGs. c The boxplot of CR-DEGs (***p < 0.001; **p < 0.01). d The PPI network of CR-DEGs. Plots represent genes, and the lines between each plot represent interaction between the proteins coded by these genes. e The co-expression network of CR-DEGs. Color scale represents the degree of expression levels’ association (red line, positive correlation; blue line, negative correlation)