Table 6.

Summary of mice stem cell research

Author Year Reference	Model	Source and dose	Route and timing	Main findings
Fang, Chao[73]	Wild-type Kunbai mice (Buslfan-induced testis)	MSCs were isolated from the bone marrow of male dairy Goat fetuses at 3rd month gestation Dose 20 μl of the gMSCs (30 to 50 × 106 cells /ml	Via the efferent ductules of the testis	- Goat MSCs exhibited male germ cell and spermatocyte markers, indicating that they had the ability to develop into male germ cells and aid spermatogenesis in endogenous germ cell-depleted patients via xenotransplantation - This shows that these cells provide a new source of male germ cells that could be exploited in the creation of male germ cells for various reproductive investigations
Abd Allah, Pasha[74]	Mice (Buslfan-induced testis)	Human umbilical cord blood stem cells and UCB-MSCs Dose 1 × 105 cells	Intra-testicular	- After mice were given Busulfan via interperitoneal injection to induce azoospermia, their testes showed severe shrinkage, deformed seminiferous tubules (most of which did not contain sperms), and widely separated spermatogenic cells, indicating degeneration - The normal architecture of the testis was restored after MSC transplantation, according to histological inspection of the tissues. A thin connective tissue capsule encased it. The stratified germinal epithelium lined the seminiferous tubules, which were tightly packed - In the group treated with HSCs, despite enhanced vascularity indicated by congested blood arteries, most seminiferous tubules still revealed dilated lumens not containing sperms with a substantial drop in spermatogenic cells