Table 7.

Hamster and Guinea pig stem cell research

Author Year Reference	Model	Source and dose	Route and timing	Main findings
Vahdati, Fathi [75]	Hamsters (Buslfan-induced azospermia)	BM-MSCs Dose (106 cells)	Injected into the lumen of the seminiferous tubules 35 days after the last Busulfan injection	- Spermatogenesis could be induced by injecting BM-MSCs - Transplantation of BMSCs into hamster seminiferous tubules resulted in fast healing of pathological abnormalities in testicular tubules - Because BM-MSCs are hypo-immunogenic and have immunosurveillance or immunosuppressive qualities, they may be a good candidate for allogeneic cell transplantation
Hajihoseini, Vahdati [76]	Male outbred Dunkin–Hartley guinea pigs induced azospermia by Busulfan	BM-MSCs Dose (106 cells)	Injected into the lumen of the seminiferous tubules 35 days after the last Busulfan injection	- BM-MSCs injection in Busulfan-induced azoospermic guinea pigs could induce spermatogenesis - Busulfan-treated Guinea pigs were examined histo-pathologically before and after receiving bone marrow–derived mesenchymal stem cells (BM-MSCs). The absence of germinal layer cells in the seminiferous tubules of Busulfan-treated testes indicates the spermatogensis; however, most seminiferous tubules appeared to have spermatogenic cells after treatment with BM-MSCs