TABLE 2.

The effect estimates of the Mendelian randomization (MR) analysis.

Exposure	Outcome	MR method	β	se	Lo-CI	Up-CI	p-value
IGF-1	Vitamin D	MR-Egger	0.018999812	0.01520897	−0.010809769	0.048809393	0.213195575
		Weighted median	0.031096407	0.011584079	0.008391612	0.053801201	0.007265815
		Inverse-variance weighted	0.020621847	0.007743419	0.005444747	0.035798947	0.007741403
		Simple mode	0.020899676	0.028156206	−0.034286488	0.07608584	0.458882307
		Weighted mode	0.027161608	0.012425803	0.002807034	0.051516182	0.030106294
Vitamin D	IGF-1	MR-Egger	0.157114122	0.232955357	−0.299478379	0.613706622	0.537003558
		Weighted median	0.144360498	0.056881533	0.032872694	0.255848302	0.011151505
		Inverse-variance weighted	0.182848013	0.062131121	0.061071015	0.30462501	0.003251139
		Simple mode	0.133477074	0.092006864	−0.04685638	0.313810528	0.206555075
		Weighted mode	0.143187284	0.069061923	0.007825915	0.278548654	0.092847198
IGF-1	Serum 25-hydroxyvitamin D	MR-Egger	0.021265266	0.015677295	−0.009462233	0.051992765	0.176011551
		Weighted median	0.025650252	0.010171023	0.005715047	0.045585457	0.011672456
		Inverse-variance weighted	0.041381371	0.008023283	0.025655736	0.057107005	2.50054 × 10–7
		Simple mode	0.06860863	0.029507856	0.010773232	0.126444029	0.02075211
		Weighted mode	0.028706186	0.012075818	0.005037584	0.052374789	0.018090546
Serum 25-hydroxyvitamin D	IGF-1	MR-Egger	0.004682825	0.032548237	−0.059111719	0.068477369	0.885957799
		Weighted median	0.035994931	0.018326928	7.41526E–05	0.071915709	0.049524746
		Inverse-variance weighted	0.056769621	0.020097767	0.017377997	0.096161245	0.004732889
		Simple mode	−0.016451297	0.044220901	−0.103124263	0.070221669	0.710833648
		Weighted mode	0.025334079	0.015999703	−0.006025339	0.056693498	0.117177654