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The numbers of excluded single nucleotide polymorphisms (SNPs) and identified instrumental SNPs.
| Exposure | Outcomes | Missing outcome | Weak IV | Pleiotropy | Leave-one-out | Palindromic structure | Incompatible alleles | Wrong casual direction | Ambiguous SNPs | Eligible SNPs |
| IGF-1 | Vitamin D | 42 | 0 | 106 | 0 | 29 | 0 | 0 | 5 | 182 |
| Vitamin D | IGF-1 | 0 | 0 | 0 | 0 | 2 | 0 | 0 | 0 | 6 |
| IGF-1 | Serum 25-OHD | 31 | 0 | 31 | 0 | 8 | 1 | 0 | 9 | 293 |
| Serum 25-OHD | IGF-1 | 0 | 0 | 27 | 0 | 1 | 0 | 0 | 1 | 83 |
IV, instrumental variables; 25-OHD, 25-hydroxyvitamin D.
