(A) Locomotor activity (velocity, total distance moved [TDM], and time spent in center [TSC]) in male Flinders Sensitive and Resistant Line rats (FSLs and FRLs, respectively). Orange represents the male population in all figures. Circle dots represent FSLs treated with S-ketamine, triangle dots represent FSLs treated with saline, and square dots represent FRLs treated with saline. (B) Locomotor activity (velocity, TDM, and TSC) in female FSLs and FRLs across the estrus cycle. Circle dots represent FSLs treated with S-ketamine, triangle dots represent FSLs treated with saline, and square dots represent FRLs treated with saline. (C) Locomotor activity (velocity, TDM, and TSC) in female FSLs and FRLs across proestrus cycle. Circle dots represent FSLs treated with S-ketamine, triangle dots represent FSLs treated with saline, and square dots represent FRLs treated with saline. (D) Locomotor activity (velocity, TDM, and TSC) in female FSLs and FRLs across diestrus cycle. Circle dots represent FSLs treated with S-ketamine, triangle dots represent FSLs treated with saline, and square dots represent FRLs treated with saline.