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Bacterial load in the lungs of Hap-I and Hap-II mice. Adult and old Hap-I (hypertensive) and Hap-II (normotensive-control) TG mice (n = 4 per group) were infected intranasally with 1 × LD100 (1 × 104 CFU) dose of F. tularensis LVS. The bacterial burdens were quantitated in the lungs on days three and five post-infection. Bacterial numbers are expressed as Log10 CFU/gram of tissue. The p-values were determined using two-way ANOVA. **p < 0.01; ***p < 0.001; ****p<0.0001.
