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. 2023 Mar 7;16(1):133–159. doi: 10.1016/j.jcmgh.2023.03.001

Figure 11.

Figure 11

ScRNA-seq revealed FSP1 as a potent therapeutic target in HCC. (A) tSNE plot showed further clustering of T cells into 6 subsets. (B) Percentage change of T cell subsets revealed an increase in proliferating and exhausted CD8+ T cells upon iFSP1 treatment. (C) tSNE plots showed the expression level of T cell exhaustion markers. (D) tSNE plots showed the expression level of cytotoxic markers. (E) Average expression level of Cxcl9 and Cx3cl1 were induced upon iFSP1 treatment in DC and macrophage subsets. (F) Average expression level of Cd40 in DC and macrophage subsets and Pdcd1 in T cell subsets were induced upon iFSP1 treatment. (G) Left: Violin plots showed the expression level of Gpx4 and Fsp1in major immune cell populations. Right: Violin plots showed the expression level of Slc3a2 and Slc7a11 in major immune cell populations. B: Error bars indicate 95% confidence interval. C‒G: Expression: normalized expression.