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. 2023 Mar 7;16(1):133–159. doi: 10.1016/j.jcmgh.2023.03.001

Figure 3.

Figure 3

FSP1 is regulated by NRF2 and MAF in human HCC. (A) Left: Knockdown of MAF in Huh7 cells is confirmed by RT-qPCR. Right: Knockdown of MAF in Huh7 cells significantly downregulated FSP1 expressions at mRNA level as confirmed by RT-qPCR. (B) Activation of NRF2 upon treatments of 0.01, 0.1, 1 μM NRF2 activator CDDO-Im resulted in dose-dependent upregulation of FSP1 mRNA expressions in MHCC97L, PLC/PRF/5, and Huh7 cells as confirmed by RT-qPCR. ∗P < .05, ∗∗∗P < .001, ∗∗∗∗P < .0001 vs NTC or 0 μM as indicated. Error bars indicate mean ± SD. Student t test.