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. 2023 May 17;10:1161893. doi: 10.3389/fmolb.2023.1161893

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Copyright © 2023 Pedrosa, Araujo, Cuatrecasas, Soy, López, Maurel, Sánchez-Montes, Montironi, Saurí, Sendino, Pérez, Ausania, Fernández-Esparrach, Espósito, Vaquero and Ginès.

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EUS-FNA samples are underrepresented in CAF and EMT related genes but enriched in immunological genes. (A) Volcano plot depicting gene expression differences in cytological samples versus surgical samples. Highly statistically significant genes fall at the top of the plot above the horizontal lines. p-values were adjusted for the False Discovery Rate (FDR) (adj. p-value). The dashed horizontal lines indicate various adj. p-values. The 40 most statistically significant genes are labelled in the plot. Genes were colored if the resulting adj. p-value was below the given p-value threshold based on log2 (fold-change) differential gene expression. (B, C) Left: Heatmap of reference genes related to CAF and EMT phenotypes (B) and to the immune response features (C) in cytological and surgical samples Right: Boxplots showing statistical differences in the relative RNA expression of selected CAF and EMT (B) and immune related genes (C) among cytological and surgical samples (asterisks indicate significant genes between cytological and surgical samples shown in the volcano plot).