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. 2023 May 17;10:1161893. doi: 10.3389/fmolb.2023.1161893

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Copyright © 2023 Pedrosa, Araujo, Cuatrecasas, Soy, López, Maurel, Sánchez-Montes, Montironi, Saurí, Sendino, Pérez, Ausania, Fernández-Esparrach, Espósito, Vaquero and Ginès.

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Pathological evaluation correlates with transcriptomic data confirming low stromal representation in EUS-FNA samples. (A) Representative images of EUS-FNA cell blocks and surgical specimens of PDAC immunostained with α-SMA. Cell block cellularity is mainly composed of epithelial cells (blue staining, red arrows), inflammatory cells on the background (green arrows), with little representation of stroma, positive for α-SMA immunostaining (brown staining, black arrows). Surgical specimens contain abundant fibroblast rich stroma with intense positivity for α-SMA (brown staining, black arrows) surrounding tumoral epithelium (blue staining red arrows). (B) Percentage of CAFs, immune cells and epithelial cancer cells in cytological and surgical samples (***, p-value <0.001). (C) Correlation matrix of % of stromal cell types and selected gene stromal cell markers in EUS-FNA and surgical samples. Spearman’s rank correlation method, paired.