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. 2023 May 17;13:1172298. doi: 10.3389/fcimb.2023.1172298

Figure 1.

Figure 1

Treatment of B. amyloliquefaciens alleviated S. japonicu-induced hepatic and intestinal granulomas in mice. (A) Experimental design schedule for the study. (B) Changes in relative body weight among the four groups. Seven mice were included from each group for calculation on days 0, 12, 24, and 36. Meanwhile, seven mice in the PBS group, seven mice in the BA group, four mice in the SJ group, and five mice in the SJBA group were included in the calculation on the 45th day. Data were analyzed by one-way analysis of variance (ANOVA) and Fisher’s least significant difference (LSD) multiple comparison posttest. (C) H&E staining and Masson’s trichrome staining of the small intestine and liver. The numbers in the lower right represent the magnification of images. The black arrows indicated granulomas. The red arrows indicated fibrosis. Blue arrows indicated eggs of S. japonicum. (D) The percentage of granuloma area in the small intestine. (E) The percentage of granuloma area in the liver. The data were analyzed by the Kruskal–Wallis test. (F) The percentage of fibrosis area in the liver. The data were analyzed by one-way ANOVA and LSD’s multiple comparison posttest. (G) The hydroxyproline content in the liver. Data were analyzed by one-way ANOVA and LSD’s multiple comparison posttest. *P <0.05; **P <0.01; ****P <0.0001.