Table 5.
Efficacy indicators and end point evaluation.
| Cases | ABCD response | ECOG | Fungal burden | Imaging remission | Prognosis | |||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 2 weeks | 4 weeks | End of treatment | 2 weeks | 4 weeks | Negative or not | Time, (days) | 2 weeks | 4 weeks | Week 4 | Week 8 | Week 12 | |
| 1 | PR | PR | PR | 2 | 2 | Yes | 8 | Yes | Yes | Survival | Survival | Survival |
| 2 | PR | PR | PR | 1 | 3 | No | / | Yes | Yes | Survival | Death# | Death |
| 3 | PR | PR | CR | 1 | 1 | No | / | Yes | Yes | Survival | Survival | Survival |
| 4 | PR | PR | PR | 1 | 1 | No | / | Yes | Yes | Survival | Survival | Survival |
| 5 | PR | /* | / | 4 | / | No | / | Yes | / | Death# | Death | Death |
| 6 | PR | PR | PR | 2 | 2 | No | / | Yes | Yes | Survival | Survival | Survival |
| 7 | PR | /* | / | 1 | / | Yes | 17 | Yes | / | Death# | Death | Death |
| 8 | PR | PR | PR | 3 | 2 | Yes | 33 | Yes | Yes | Survival | Survival | Survival |
| 9 | PR | PR | PR | 1 | 1 | Yes | 23 | Yes | Yes | Survival | Survival | Survival |
*the total treatment duration for Case 5 and Case 7 was less than 4 weeks. #Case 7 died of massive hemoptysis caused by mucormycosis, and Case 5 died due to recurrence of the primary disease after less than 4 weeks of treatment; Case 2 died due to co-bacterial infection between 4 and 8 weeks. ECOG, Eastern Cooperative Oncology Group; PR, partial response; CR, complete response. /, data not available.