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. 2023 May 17;14:1161718. doi: 10.3389/fimmu.2023.1161718

Table 1.

Clinical characteristics for all patients.

Characteristics Total cohort
(n=146) (%)
Immunotherapy P value
Without (n=66) (%) With (n=80) (%)
Gender 0.080
Male 78 (53.4) 30 (45.5) 48 (60.0)
Female 68 (46.6) 36 (54.5) 32 (40.0)
Age(y) 0.898
<65 81 (55.5) 37 (56.1) 44 (55.0)
≥65 65 (44.5) 29 (43.9) 36 (45.0)
Smoking History 0.091
Never-smoker 84 (57.5) 43 (65.2) 41 (51.2)
Former/current smoker 62 (42.5) 23 (34.8) 39 (48.8)
TNM stage 0.215
III 13 (8.9) 8 (12.1) 5 (6.3)
IV 133 (91.1) 58 (87.9) 75 (93.7)
Histology 0.196
Squamous 2 (1.4) 0 (0.0) 2 (2.5)
Adenocarcinoma 144 (98.6) 66 (100.0) 78 (97.5)
ECOG-PS 0.472
0-1 136 (93.2) 63 (95.5) 73 (91.2)
2 10 (6.8) 3 (4.5) 7 (8.8)
EGFR mutation type 0.298
19del 59 (40.4) 31 (47.0) 28 (35.0)
21L858R 75 (51.4) 31 (47.0) 44 (55.0)
Otders 12 (8.2) 4 (6.0) 8 (10.0)
Primary brain metastasis 0.210
Yes 43 (29.5) 16 (19.4) 27 (23.6)
No 103 (70.5) 50 (46.6) 53 (56.4)
Primary liver metastasis 0.517
Yes 11 (7.5) 6 (9.1) 5 (6.3)
No 135 (92.5) 60 (90.9) 75 (93.7)
EGFR-TKI 0.358
Gefitinib 51 (34.9) 21 (31.9) 30 (37.5)
Icotinib 53 (36.3) 22 (33.3) 31 (38.8)
Erlotinib 7 (4.8) 5 (7.6) 2 (2.5)
Afatinib 10 (6.8) 4 (6.1) 6 (7.5)
Osimertinib 23 (15.8) 13 (19.6) 10 (12.5)
Dacomitinib 2 (1.4) 1 (1.5) 1 (1.2)