Table 3.

Univariable and multivariable cox regression analysis for overall survival (OS) in all patients.

Characteristics	Univariable analysis			Multivariable analysis
	HR	95%Cl	P	HR	95%Cl	P
Gender			0.322
Male	reference
Female	0.767	0.454-1.297
Age(y)			0.122			0.130
<65	reference			reference
≥65	1.524	0.894-2.600		1.519	0.885-2.610
Smoking History			0.734
Yes	reference
No	0.915	0.548-1.528
TNM stage			0.400
III	reference
IV	1.441	0.616-3.372
Histology			0.368
Squamous	reference
Adenocarcinoma	0.377	0.195-1.665
ECOG-PS			0.006			0.008
0-1	reference			reference
2	2.210	1.191-3.841		2.270	1.112-3.877
EGFR mutation type			0.531
19del	reference
21L858R	0.789	0.452-1.379	0.406
Otders	1.231	0.502-3.015	0.650
Primary brain metastasis			0.745
Yes	reference
No	0.912	0.522-1.592
Primary liver metastasis			0.032			0.037
Yes	reference			reference
No	0.457	0.194-0.772		0.550	0.230-0.793
Post-line immunotderapy			0.012			0.005
Yes	reference			reference
No	1.963	1.163-3.314		2.184	1.273-3.746

ECOG-PS, Eastern cooperative oncology group-performance status; EGFR, epidermal growth factor receptor.

The bold values mean these characters are both significant in univariable and multivarible analysis.