TABLE 4.

Predicted IC₅₀ by HM and analysis results of the property explorer applet of new designed compounds.

No.	Pre.IC50	Toxicity	LogP	Solubility	Mol weights	TPSA	Druglikeness	Drug score
31	0.758	Good	2.81	−3.65	244	89.52	0.68	0.69
31a	0.139	Good	1.43	−2.31	251	113.3	0.47	0.75
31b	0.446	Good	2.73	−3.79	302	115.8	−3.46	0.42
31c	0.366	Good	2.81	−3.65	244	89.52	−0.11	0.61
31d	0.212	Good	3.42	−4.39	278	89.52	0.45	0.59
31e	0.449	Good	2.41	−3.55	246	89.52	−2.93	0.45