Table 2.
Distribution of Pathologic Factors among Patients with <2 cm Low/Intermediate Grade, Non-functional, PNETs from the US-NETSG Database who underwent Curative-intent Resection from 2000–2016, Stratified by Lymph Node-Positivity.
| Pathologic Factors | Lymph Node Negative (n=287) |
Lymph Node Positive (n=22) |
p-valuea |
|---|---|---|---|
| Location of Tumor in Pancreas, n (%) | 0.003 | ||
| Proximal | 55 (23) | 12 (55) | |
| Distal | 183 (77) | 10 (45) | |
|
| |||
| Tumor size | 0.677 | ||
| <1 cm | 57 (24) | 4 (18) | |
| 1–1.5 cm | 114 (48) | 10 (46) | |
| ≥1.5 cm | 67 (28) | 8 (36) | |
|
| |||
| AJCC T-Stage, n (%) | 0.006 | ||
| T1/T2 | 231 (97) | 18 (82) | |
| T3/T4 | 6 (3) | 4 (18) | |
|
| |||
| Tumor Differentiation, n (%) | 0.646 | ||
| Well | 199 (92) | 16 (89) | |
| Moderate | 17 (8) | 2 (11) | |
|
| |||
| Ki-67 Index, n (%) | 0.090 | ||
| <3% | 136 (77) | 10 (56) | |
| 3–20% | 41 (23) | 8 (44) | |
|
| |||
| Mitotic Rate (per 10 HPF), n (%) | 0.081 | ||
| <2 | 141 (92) | 9 (75) | |
| 2–20 | 12 (8) | 3 (25) | |
|
| |||
| Final Resection Status, n (%) | 0.065 | ||
| R0b | 222 (94) | 18 (82) | |
| R1b | 15 (6) | 4 (18) | |
|
| |||
| Lymphovascular Invasion, n (%) | <0.001 | ||
| Negative | 186 (92) | 7 (39) | |
| Positive | 17 (8) | 11 (61) | |
|
| |||
| Perineural Invasion, n (%) | 0.005 | ||
| Negative | 161 (88) | 11 (61) | |
| Positive | 21 (12) | 7 (39) | |
Abbreviations: AJCC, American Joint Committee on Cancer; HPF, high power fields;
a
Statistical significance is indicated by a p<0.05.
b
R0 resection refers to negative margins on pathologic review of the specimen, while R1 resection refers to positive margins on pathologic review of the specimen.