Table 3.
Association of Pathologic Factors with Risk for Lymph Node Positivity in Patients with <2 cm Low/Intermediate Grade, Non-functional, PNETs from the US-NETSG Database who underwent Curative-intent Resection from 2000–2016.
| Logistic Regression | ||
|---|---|---|
| Lymph Node Positivity | ||
| Pathologic Factors | OR (95% CI) | p-valuea |
| Tumor Location in Pancreas | ||
| Distal | Ref | -- |
| Proximal | 4.0 (1.6–9.7) | 0.002 |
|
| ||
| Tumor Size | ||
| <1 cm | Ref | -- |
| 1–1.5 cm | 1.25 (0.4–4.2) | 0.716 |
| ≥1.5 cm | 1.7 (0.5–5.9) | 0.405 |
|
| ||
| Tumor Differentiation | ||
| Well | Ref | -- |
| Moderate | 1.5 (0.3–6.9) | 0.631 |
|
| ||
| Ki-67 Index | ||
| <3% | Ref | -- |
| 3–20% | 2.7 (1.0–7.2) | 0.054 |
|
| ||
| Final Resection Status | ||
| R0 | Ref | -- |
| R1 | 3.3 (1.0–11.0) | 0.052 |
|
| ||
| Mitotic Rate (per 10 HPF) | ||
| <2 | Ref | -- |
| 2–20 | 3.9 (0.9–16.4) | 0.062 |
|
| ||
| Lymphovascular Invasion | ||
| Negative | Ref | -- |
| Positive | 17.2 (5.9–50.1) | <0.001 |
|
| ||
| Perineural Invasion | ||
| Negative | Ref | -- |
| Positive | 4.9 (1.7–14.0) | 0.003 |
|
| ||
| Advanced T Stage | ||
| T1/T2 | Ref | -- |
| T3 | 8.6 (2.2–33.1) | 0.002 |
Abbreviations: OR, odds ratio; CI, confidence interval; HPF, high power fields;
a
Statistical significance is indicated by a p<0.05.
Bold values indicate preoperatively measurable variables through imaging or biopsy.