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. 2023 Apr 13;193(2):146–165. doi: 10.1093/toxsci/kfad033

Figure 7.

Figure 7.

Genotoxicity by exposure to PG/VG, menthol, and tobacco flavors in C57BL/6J mouse lung tissue. C57BL/6J male and female mice were exposed to PG/VG, menthol, menthol 6 mg nicotine, tobacco, and tobacco 6 mg nicotine 2 h/day for three consecutive days in SCIREQ whole-body exposure chamber. Mice were euthanized ∼24 h postexposure and mouse lung tissues were homogenized and measured genotoxicity markers, A, H2AX; B, MDM2; C, p21; and D, ATR by measuring net median florescence intensity (MFI) normalized to total protein. Data are shown as mean ± SEM. *p < .05, **p < .01, and ***p < .001 versus respective air group per strain (1-way ANOVA) (N = 3–10 per group).