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. 2023 Apr 13;193(2):146–165. doi: 10.1093/toxsci/kfad033

Table 2.

Tobacco and menthol E-liquid flavor chemical constituents

Tobacco Flavor
Menthol Flavor
CAS Chemical Name CAS Chemical Name
54-11-5 Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)- 54-11-5 Pyridine, 3-(1-methyl-2-pyrrolidinyl)-, (S)-
4940-11-08 00:00:00 Ethyl maltol 4940-11-08 00:00:00 Ethyl maltol
71-55-6 Ethane, 1,1,1-trichloro- 71-55-6 Ethane, 1,1,1-trichloro-
623-37-0 Hexan-3-ol 623-37-0 Hexan-3-ol
1000152-79-7 Cyclopentane, 1,2,3,4,5-pentamethyl- 1000152-79-7 Cyclopentane, 1,2,3,4,5-pentamethyl-
26456-76-8 2-Hexene, 3,5,5-trimethyl- 26456-76-8 2-Hexene, 3,5,5-trimethyl-
75-85-4 Amylene hydrate 75-85-4 Amylene hydrate
40467-04-7 2-Hexene, 2,5,5-trimethyl- 40467-04-7 2-Hexene, 2,5,5-trimethyl-
693-65-2 Amyl ether 693-65-2 Amyl ether
110-98-5 2-Propanol, 1,1′-oxybis- 110-98-5 2-Propanol, 1,1′-oxybis-
1678-82-6 Menthane <trans-para-> 1678-82-6 Menthane <trans-para->
116-09-6 Hydroxyacetone 116-09-6 Hydroxyacetone
2568-25-4 1,3-Dioxolane, 4-methyl-2-phenyl- 2568-25-4 1,3-Dioxolane, 4-methyl-2-phenyl-
60-12-8 Phenylethyl alcohol 60-12-8 Phenylethyl alcohol
104-67-6 2(3H)-Furanone, 5-heptyldihydro- 104-67-6 2(3H)-Furanone, 5-heptyldihydro-
78-70-6 Linalool 78-70-6 Linalool
98-55-5 Terpineol <alpha-> 98-55-5 Terpineol <alpha->
104-76-7 1-Hexanol, 2-ethyl- 104-76-7 1-Hexanol, 2-ethyl-
121-33-5 Vanillin 1490-04-6 Menthol
118-71-8 Maltol 121-32-4 Vanillal
106-62-7 1-Propanol, 2-(2-hydroxypropoxy)- 14371-10-9 Cinnamaldehyde <(E)->
56-81-5 Glycerin 2890-62-2 Ethanone, 1-(1-methylcyclohexyl)-
6214-01-03 00:00:00 1,2-Propanediol, 2-acetate 563-80-4 2-Butanone, 3-methyl-
68527-74-2 Vanillin propylene glycol acetal 53951-43-2 1,3-Dioxolane-2-methanol,2,4-dimethyl-
706-14-9 2(3H)-Furanone, 5-hexyldihydro- 107-87-9 Propyl methyl ketone
100-51-6 Benzyl alcohol 7149-26-0 Linalyl anthranilate
106-61-6 1,2,3-Propanetriol, 1-acetate 80-71-7 2-Cyclopenten-1-one,2-hydroxy-3-methyl-
627-69-0 1,2-Propanediol, 1-acetate 765-70-8 Cyclopentane-1,2-dione <3-methyl->
1000378-33-1 1-[(1-Propoxypropan-2-yl)oxy]propan-2-yl acetate 928-96-1 Hex-(3Z)-enol
1754-62-7 2-Propenoic acid, 3-phenyl-, methyl ester, (E)- 67634-12-2 Lyral
102-62-5 Glycerol 1,2-diacetate 119-61-9 Benzophenone
1120-36-1 Tetradec-1-ene 84-66-2 Diethyl phthalate
102-76-1 Triacetin 928-97-2 3-Hexen-1-ol, (E)-
77-93-0 Triethyl citrate 54120-69-3 1,4-Dioxane-2,6-dimethanol
23726-91-2 Damascone <(E)-beta-> 1319-88-6 Benzaldehyde glyceryl acetal
621-59-0 Benzaldehyde, 3-hydroxy-4-methoxy- 105-68-0 Propanoate <isopentyl->
1490-04-6 Cyclohexanol, 5-methyl-2-(1-methylethyl)- 556-52-5 Glycidol
121-32-4 Ethyl vanillin 106-27-4 Butanoic acid, 3-methylbutyl ester
14371-10-9 Cinnamaldehyde <(E)-> 3623-51-6 Neomenthol
2890-62-2 Ethanone, 1-(1-methylcyclohexyl)- 491-07-6 Isomenthone
563-80-4 2-Butanone, 3-methyl- 7786-67-6 Isopulegol
53951-43-2 1,3-Dioxolane-2-methanol, 2,4-dimethyl- 15932-80-6 Pulegone
107-87-9 Propyl methyl ketone 470-82-6 Eucalyptol
7149-26-0 Linalyl anthranilate 51174-12-0 2,4,4-Trimethyl-1-hexene
80-71-7 2-Cyclopenten-1-one, 2-hydroxy-3-methyl- 584-03-2 1,2-Butanediol
765-70-8 Cyclopentane-1,2-dione <3-methyl-> 1455-20-5 Butylthiophene <2->
928-96-1 Hex-(3Z)-enol 99-49-0 Carvone
67634-12-2 Lyral 16409-45-3 Cyclohexanol, 5-methyl-2-(1-methylethyl)-, acetate
119-61-9 Benzophenone 29141-10-4 (1R,2R,5S)-5-Methyl-2-(prop-1-en-2-yl)cyclohexanol
84-66-2 Diethyl phthalate 75-07-0 Acetic aldehyde
928-97-2 3-Hexen-1-ol, (E)- 6485-40-1 (−)-Carvone
65-85-0 Benzoic acid 15356-70-4 d(+) Menthol
120-57-0 Piperonal 1197-07-5 Carveol <trans->
97-54-1 Isoeugenol 14073-97-3 l-Menthone
97-53-0 Eugenol 589-98-0 3-Octanol
2051-49-2 Hexanoic acid, anhydride 4819-67-4 Delphone
6290-17-1 Ethyl acetoacetate propylene glycol ketal  2216-51-5 Levomenthol
93-58-3 Benzoic acid, methyl ester 89-81-6 2-Cyclohexen-1-one,3-methyl-6-(1-methylethyl)-
554-12-1 Methyl propionate 89-82-7 Pulegone
68527-76-4 Ethylvanillin propylene glycol acetal, cis- 20405-60-1 Dihydrocarvyl acetate
123-11-5 Benzaldehyde, 4-methoxy- 112-30-1 Decyl alcohol
554-14-3 Thiophene <alpha-methyl-> 2230-87-7 Neomenthyl acetate
120-51-4 Benzyl benzoate 3391-87-5 (+)-Menthone
166273-38-7 Pentanoic acid, 5-hydroxy-, 2,4-di-t-butylphenyl esters 104-46-1 Anethole
104-61-0 2(3H)-Furanone, dihydro-5-pentyl- 122-00-9 Acetophenone <4′-methyl->
584-02-1 Pentanol <3-> 103-54-8 Acetic acid, cinnamyl ester
61683-99-6 1,3-Benzodioxole, 5-(4-methyl-1,3-dioxolan-2-yl)- 21040-45-9 Cinnamyl acetate <(E)->
134-20-3 Methyl anthranilate 52154-82-2 Mentha-2,8-dien-1-ol <trans-, para->
74421-06-0 2-Heptene, 5-ethyl-2,4-dimethyl- 127-91-3 Pinene <beta->
111-27-3 1-Hexanol 13877-93-5 Caryophyllene <(E)->
104-50-7 Octalactone <gamma-> 1000155-47-0 3-Cyclohexen-1-one, 2-isopropyl-5-methyl-
616-44-4 Thiophene, 3-methyl- 4180-23-8 Anethole <(E)->
77-83-8 Ethyl 3-methyl-3-phenylglycidate (Z) 7212-40-0 2-Cyclohexen-1-ol,1-methyl-4-(1-methylethenyl)-, trans-
104-21-2 Benzenemethanol, 4-methoxy-, acetate 57-71-6 2,3-Butanedione, monooxime
105-13-5 Benzenemethanol, 4-methoxy- 1000364-16-7 3-Methylbenzyl alcohol, TBDMS derivative
76-09-5 2,3-Butanediol, 2,3-dimethyl- 1671-77-8 1-Pentanone, 1-(4-methylphenyl)-
106-24-1 Geraniol 35852-46-1 Pentanoate <cis-3-hexenyl->
105-21-5 2(3H)-Furanone, dihydro-5-propyl- 40625-96-5 5-Methyl-2,4-diisopropylphenol
19464-92-7 Ethyl methylphenylglycidate 1000400-22-0 4H-thiopyran-4-one, 2,3-dihydro-2-phenyl-
1126-51-8 5-Oxotetrahydrofuran-2-carboxylic acid, ethyl ester 1139-30-6 Caryophyllene oxide
10482-56-1 l-.alpha.-Terpineol 619-01-2 Cyclohexanol,2-methyl-5-(1-methylethenyl)-
17003-99-5 2-Nonene, 3-methyl-, (E)- 80-56-8 Pinene <alpha->
532-12-7 Pyridine, 3-(3,4-dihydro-2H-pyrrol-5-yl)- 118-65-0 Isocaryophyllene
7145-23-5 3-Hexene, 2,3-dimethyl- 18172-67-3 Bicyclo[3.1.1]heptane,6,6-dimethyl-2-methylene-, (1S)-
10473-13-9 3-Buten-2-ol, 2,3-dimethyl- 42436-07-7 cis-3-Hexenyl phenyl acetate
118-93-4 Acetophenone <2′-hydroxy-> 50639-00-4 2-Hexen-1-ol, 2-ethyl-
2785-89-9 Phenol, 4-ethyl-2-methoxy- 1000145-04-8 1-Methyl-4-isopropyl-cyclohexyl 2-hydroperfluorobutanoate
486-56-6 Cotinine 1000139-76-4 Pentanoic acid, 4-methyl-, 1-buten-1-yl ester
614-97-1 5-Methylbenzimidazole 13466-78-9 3-Carene
92-48-8 2H-1-Benzopyran-2-one, 6-methyl- 149-57-5 Hexanoic acid <2-ethyl->
108-87-2 Hexahydrotoluene 4403-13-8 Ethylene glycol, TMS derivative
864685-64-3 2,3,4,4-Tetramethyl-5-methylidenecyclopent-2-en-1-one
1000307-63-7 p-Anisic acid, 4-cyanophenyl ester
1000343-91-2 Isophthalic acid, ethyl tridec-2-ynyl ester
65079-19-8 6-Quinolinamine, 2-methyl-
13588-28-8 1-Propanol, 2-(2-methoxypropoxy)-
54644-41-6 Propanoic acid, 2,2-dimethyl-, 2-(1,1-dimethylethyl)phenyl ester
7150-55-2 1-Butanone, 4-chloro-1-(4-hydroxyphenyl)-