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. 2023 May 30;13(5):e071397. doi: 10.1136/bmjopen-2022-071397

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© Author(s) (or their employer(s)) 2023. Re-use permitted under CC BY-NC. No commercial re-use. See rights and permissions. Published by BMJ.

This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial. See: http://creativecommons.org/licenses/by-nc/4.0/.

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Titres of anti-spike and anti-receptor binding domain IgG levels following first, second, third and fourth vaccinations: (A) All IMIDs, (B) IA, (C) SARDs, (D) IBD and (E) MS. Data for seroconverters only. IgG levels natural log-transformed (LN). Unadjusted p values: *p<0.0001, **p≤0.001, ***p≤0.00, ****p<0.05. IA, inflammatory arthritis; IBD, inflammatory bowel disease; IMIDs, immune-mediated inflammatory disease; MS, multiple sclerosis; RBD, receptor binding domain; SARD, systemic autoimmune rheumatic disease; V1, first vaccine; V2, second vaccine; V3, third vaccine; V4, fourth vaccine.