Table 2.

Study visits and procedures schedule

Study procedure	First ANC clinic visit	Routine ANC clinic visits	End of pregnancy	1 month after end of pregnancy	Unscheduled visits	Infant assessment (birth and 1 month)
Inclusion/exclusion criteria check	X
Written informed consent	X
Demographics, socioeconomic/medical history	X				X
COVID-19 screening*	X	X			X	X
Record of medications/morbidity	X	X	X	X	X
Physical/clinical examination	X		X		X
Gestational age	X	X	X		X
Temperature				X	X	X
Blood pressure	X		X	X	X
Weight	X	X		X	X
Height	X
MUAC	X			X
Presence of proteins in urine	X
CD4 count†	X
HIV viral load†	X		X
SARS-CoV-2 serology	X		X
Malaria blood PCR	X
Blood smear	‡	‡	X	X	‡
Haemoglobin test	X		X	X
Peripheral venous blood (mother)	X		X
Cord blood			X
Placental biopsy			X
Placental impression smears			X
Breast milk (SARS-CoV-2)			X	X

*In participants with suggestive symptoms/signs of COVID-19 (fever, cough, shortness of breath, sudden onset of anosmia, ageusia or dysgeusia), except in a subsample of 100 participants at enrolment among whom it will be performed regardless of presence of symptoms.

†Only in HIV-infected women.

‡Only in women passively reporting sick AND presenting with malaria-related signs/symptoms (fever (≥37.5°C) or having a history of fever in the past 24 hours, arthromyalgia or headache), as per the national management guidelines.

ANC, antenatal care; MUAC, middle upper arm circumference.