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. 2022 Dec 1;108(6):1604–1615. doi: 10.3324/haematol.2022.281222

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Figure 5. — Comparison of STAT3 activation (pSTAT3^Tyr705) and PD-L1 expression in ALK-negative anaplastic large cell lymphoma with or without a DUSP22 rearrangement. (A, D) Negative pSTAT3^Tyr705 (A) and PD-L1 (D) expression in a DUSP22-rearranged case. (B, E) Diffuse positivity of pSTAT3^Tyr705 (B) and PD-L1 (E) in a case without a DUSP22-rearrangement. (C, F) The percentage of pSTAT3^Tyr705-positive (C) or PD-L1-positive (F) lymphoma cells in DUSP22-rearranged cases of anaplastic large cell lymphoma is significantly lower than that in cases without a DUSP22 rearrangement. DUSP22-R: with DUSP22 rearrangement; DUSP22-NR: without DUSP22 rearrangement.