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. 2022 Dec 1;108(6):1604–1615. doi: 10.3324/haematol.2022.281222

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Figure 6. — DUSP22 rearrangement has no prognostic significance in patients with ALK-negative anaplastic large cell lymphoma regardless of International Prognostic Index score, stage, age, or transplantation status. (A, B) Comparison of overall survival (A) and progression-free survival (B) among the patients with ALK+ anaplastic large cell lymphoma (ALCL), DUSP22-R (all were TP63-NR) ALK-negative ALCL, DUSP22-NR/TP63-NR (triple-negative) ALK-negative ALCL, and DUSP22-NR/TP63-R ALK-negative ALCL. *P<0.05, when comparing ALK+ ALCL versus DUSP22-R ALK-negative ALCL or comparing ALK+ ALCL versus DUSP22-NR/TP63-NR ALK-negative ALCL. (C, D) Comparison of overall survival in patients with International Prognostic Index score ≥3 (C) and <3 (D). (E, F) Comparison of overall survival in patients with stage III-IV (E) and stage I-II (F) disease. (G, H) Comparison of overall survival in patients aged ≥50 years (G) and <50 years (H). (I, J) Comparison of overall survival in patients with stem cell transplantation (I) and without (J). DUSP22-R: with DUSP22 rearrangement; DUSP22-NR: without DUSP22 rearrangement; TP63-R: with TP63 rearrangement; TP63-NR: without TP63 rearrangement; IPI: International Prognostic Index; OS: overall survival; PFS: progression-free survival; SCT: stem cell transplant. (C-J) TP63-R cases were excluded.